| http://purl.uniprot.org/citations/11035039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11035039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11035039 | http://www.w3.org/2000/01/rdf-schema#comment | "The ectodermal dysplasia receptor (EDAR) is a recently isolated member of the tumor necrosis factor receptor family that has been shown to play a key role in the process of ectodermal differentiation. We present evidence that EDAR is capable of activating the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways and that these activities are impaired in mutants lacking its death domain or those associated with anhidrotic ectodermal dysplasia and the downless phenotype. Although EDAR possesses a death domain, it did not interact with the death domain-containing adaptor proteins TRADD and FADD. EDAR successfully interacted with various TRAF family members; however, a dominant-negative mutant of TRAF2 was incapable of blocking EDAR-induced nuclear factor-kappaB or JNK activation. Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008356200"xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008356200"xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Chaudhary P.M."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Chaudhary P.M."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Eby M.T."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Eby M.T."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Jasmin A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/author | "Jasmin A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/pages | "2668-2677"xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/pages | "2668-2677"xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/title | "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/title | "The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A."xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11035039 | http://purl.uniprot.org/core/volume | "276"xsd:string |