| http://purl.uniprot.org/citations/11042166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11042166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11042166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/11042166 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated three types of cDNAs encoding novel beta1,3-N-acetylglucosaminyltransferases (designated beta3Gn-T2, -T3, and -T4) from human gastric mucosa and the neuroblastoma cell line SK-N-MC. These enzymes are predicted to be type 2 transmembrane proteins of 397, 372, and 378 amino acids, respectively. They share motifs conserved among members of the beta1,3-galactosyltransferase family and a beta1,3-N-acetylglucosaminyltransferase (designated beta3Gn-T1), but show no structural similarity to another type of beta1,3-N-acetylglucosaminyltransferase (iGnT). Each of the enzymes expressed by insect cells as a secreted protein fused to the FLAG peptide showed beta1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides but not beta1,3-galactosyltransferase activity. These enzymes exhibited different substrate specificity. Transfection of Namalwa KJM-1 cells with beta3Gn-T2, -T3, or -T4 cDNA led to an increase in poly-N-acetyllactosamines recognized by an anti-i-antigen antibody or specific lectins. The expression profiles of these beta3Gn-Ts were different among 35 human tissues. beta3Gn-T2 was ubiquitously expressed, whereas expression of beta3Gn-T3 and -T4 was relatively restricted. beta3Gn-T3 was expressed in colon, jejunum, stomach, esophagus, placenta, and trachea. beta3Gn-T4 was mainly expressed in brain. These results have revealed that several beta1,3-N-acetylglucosaminyltransferases form a family with structural similarity to the beta1,3-galactosyltransferase family. Considering the differences in substrate specificity and distribution, each beta1,3-N-acetylglucosaminyltransferase may play different roles."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m004800200"xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m004800200"xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Nakagawa S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Nakagawa S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Sekine S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Sekine S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Imai N."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Imai N."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Shiraishi N."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Shiraishi N."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Akashima T."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Akashima T."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Koizumi S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Koizumi S."xsd:string |
| http://purl.uniprot.org/citations/11042166 | http://purl.uniprot.org/core/author | "Narimatsu H."xsd:string |