http://purl.uniprot.org/citations/11042274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11042274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11042274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
http://purl.uniprot.org/citations/11042274 | http://www.w3.org/2000/01/rdf-schema#comment | "The gamma-subunit of citrate lyase (EC 4.1.3.6) contains the prosthetic group 2'-(5"-phosphoribosyl)-3'-dephospho-CoA and serves as an acyl carrier protein (ACP). We recently showed that in Escherichia coli the proteins CitG and CitX are essential for holo-ACP synthesis and provided evidence that CitG catalyzes the formation of a prosthetic group precursor from ATP and dephospho-CoA, which is subsequently attached via phosphodiester linkage to apo-ACP by CitX. Here we prove that CitG indeed catalyzes the conversion of ATP and dephospho-CoA to adenine and 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA, the predicted precursor of the prosthetic group. Furthermore, this precursor was transferred by CitX to apo-ACP, yielding holo-ACP. Thus, our proposed mechanism for holo-ACP synthesis could be verified."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)02105-0"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)02105-0"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)02105-0"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Bott M."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Bott M."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Dimroth P."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Dimroth P."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Schneider K."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/author | "Schneider K."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/pages | "165-168"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/pages | "165-168"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/title | "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/title | "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group."xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/volume | "483"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://purl.uniprot.org/core/volume | "483"xsd:string |
http://purl.uniprot.org/citations/11042274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11042274 |
http://purl.uniprot.org/citations/11042274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11042274 |