| http://purl.uniprot.org/citations/11044395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11044395 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffusible factors, including netrins and semaphorins, are believed to be important cues for the formation of neural circuits in the forebrain. Here we have examined the role of netrin 1 in the development of hippocampal connections. We show that netrin 1 and its receptor, Dcc, are expressed in the developing fimbria and in projection neurons, respectively, and that netrin 1 promotes the outgrowth of hippocampal axons in vitro via DCC receptors. We also show that the hippocampus of netrin 1-deficient mice shows a misorientation of fiber tracts and pathfinding errors, as detected with antibodies against the surface proteins TAG-1, L1 and DCC. DiI injections show that hippocampal commissural axons do not cross the midline in these mutants. Instead, when axons approach the midline, they turn ventrally and form a massive aberrant projection to the ipsilateral septum. In addition, both the ipsilateral entorhino-hippocampal and the CA3-to-CA1 associational projections show an altered pattern of layer-specific termination in netrin 1-deficient mice. Finally, optical recordings with the Ca(2+) indicator Fura 2-AM show that spontaneous neuronal activity is reduced in the septum of netrin 1-mutant mice. We conclude that netrin 1 is required not only for the formation of crossed connections in the forebrain, but also for the appropriate layer-specific targeting of ipsilateral projections and for the control of normal levels of spontaneous neural activity."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.22.4797"xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Martin M."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Tessier-Lavigne M."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Ruiz M."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Del Rio J.A."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Soriano E."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Borrell V."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Fabre M."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Alcantara S."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Aguado F."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Carmona M.A."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Yuste R."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/author | "Barallobre M.J."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/pages | "4797-4810"xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/title | "Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/11044395 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11044395 |
| http://purl.uniprot.org/citations/11044395 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11044395 |
| http://purl.uniprot.org/uniprot/#_B0QZL0-mappedCitation-11044395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11044395 |
| http://purl.uniprot.org/uniprot/#_O09118-mappedCitation-11044395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11044395 |
| http://purl.uniprot.org/uniprot/#_Q3TZP5-mappedCitation-11044395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11044395 |