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| http://purl.uniprot.org/citations/11046072 | http://www.w3.org/2000/01/rdf-schema#comment | "We explored mechanisms involved in B cell self-tolerance against brain autoantigens in a double-transgenic mouse model carrying the Ig H-chain (introduced by gene replacement) and/or the L-chain kappa (conventional transgenic) of the mAb 8.18C5, specific for the myelin oligodendrocyte glycoprotein (MOG). Previously, we demonstrated that B cells expressing solely the MOG-specific Ig H-chain differentiate without tolerogenic censure. We show now that double-transgenic (THkappa(mog)) B cells expressing transgenic Ig H- and L-chains are subjected to receptor editing. We show that in adult mice carrying both MOG-specific Ig H- and L-chains, the frequency of MOG-binding B cells is not higher than in mice expressing solely the transgenic Ig H-chain. In fact, in THkappa(mog) double-transgenic mice, the transgenic kappa(mog) L-chain was commonly replaced by endogenous L-chains, i.e., by receptor editing. In rearrangement-deficient RAG-2(-) mice, differentiation of THkappa(mog) B cells is blocked at an immature stage (defined by the B220(low)IgM(low)IgD(-) phenotype), reflecting interaction of the autoreactive B cells with a local self-determinant. The tolerogenic structure in the bone marrow is not classical MOG, because back-crossing THkappa(mog) mice into a MOG-deficient genetic background does not lead to an increase in the proportion of MOG-binding B cells. We propose that an as yet undefined self-Ag distinct from MOG cross-reacts with the THkappa(mog) B cell receptor and induces editing of the transgenic kappa(mog) L-chain in early immature B cells without affecting the pathogenic potential of the remaining MOG-specific B cells. This phenomenon represents a particular form of chain-specific split tolerance."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.9.5360"xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Iglesias A."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Dautigny A."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Pham-Dinh D."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Wekerle H."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Morales P."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Bluthmann H."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/author | "Litzenburger T."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/pages | "5360-5366"xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/title | "Development of myelin oligodendrocyte glycoprotein autoreactive transgenic B lymphocytes: receptor editing in vivo after encounter of a self-antigen distinct from myelin oligodendrocyte glycoprotein."xsd:string |
| http://purl.uniprot.org/citations/11046072 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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