| http://purl.uniprot.org/citations/11050006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11050006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11050006 | http://www.w3.org/2000/01/rdf-schema#comment | "Human granulocytes are characterized by a variety of specific effector functions involved in host defense. Several widely expressed protein kinases have been implicated in the regulation of these effector functions. A polymerase chain reaction-based strategy was used to identify novel granulocyte-specific kinases. A novel protein kinase complementary DNA with an open reading frame of 357 amino acids was identified with homology to calcium-calmodulin-dependent kinase I (CaMKI). This has been termed CaMKI-like kinase (CKLiK). Analysis of CKLiK messenger RNA (mRNA) expression in hematopoietic cells demonstrated an almost exclusive expression in human polymorphonuclear leukocytes (PMN). Up-regulation of CKLiK mRNA occurs during neutrophilic differentiation of CD34(+) stem cells. CKLiK kinase activity was dependent on Ca(++) and calmodulin as analyzed by in vitro phosphorylation of cyclic adenosine monophosphate responsive element modulator (CREM). Furthermore, CKLiK-transfected cells treated with ionomycin demonstrated an induction of CRE-binding protein (CREB) transcriptional activity compared to control cells. Additionally, CaMK-kinasealpha enhanced CKLiK activity. In vivo activation of CKLiK was shown by addition of interleukin (IL)-8 to a myeloid cell line stably expressing CKLiK. Furthermore inducible activation of CKLiK was sufficient to induce extracellular signal-related kinase (ERK) mitogen-activated protein (MAP) kinase activity. These data identify a novel Ca(++)/calmodulin-dependent PMN-specific kinase that may play a role in Ca(++)-mediated regulation of human granulocyte functions."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Coffer P.J."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Coffer P.J."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Koenderman L."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Koenderman L."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Lammers J.-W.L."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Lammers J.-W.L."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Verploegen S."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/author | "Verploegen S."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/pages | "3215-3223"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/pages | "3215-3223"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/title | "Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent protein kinase."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/title | "Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent protein kinase."xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/11050006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11050006 |
| http://purl.uniprot.org/citations/11050006 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11050006 |
| http://purl.uniprot.org/citations/11050006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11050006 |
| http://purl.uniprot.org/citations/11050006 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11050006 |