| http://purl.uniprot.org/citations/11050037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11050037 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-mitochondrial antibody response in primary biliary cirrhosis (PBC) is primarily directed at E2 components of PDC, OGDC, and BCOADC, and E3BP. Previous work has shown that the immunodominant autoreactive T-cell epitope is the PDC-E2 163-176 peptide, restricted by HLA DR53. To address molecular mimicry and cross-recognition among mitochondrial autoantigens, we analyzed reactivity, including agonism and antagonism assays, to a series of single amino acid-substituted peptides using cloned T-cell lines in PBC and controls. Interestingly, fine specificities were unique for every single T-cell clone, but the clones could be categorized into two distinct groups based on recognition motifs of the T-cell receptor (TCR) ligand: group A (170)ExDK(173) and group B (168)EIExD(172). (170)E is the most critical TCR contact residue for both groups of cloned T-cell lines, whereas (173)K and (168)E are the critical TCR contact residues for group A and group B cloned T-cell lines, respectively. More importantly, some group A-cloned T-cell lines cross-reacted to human E3BP 34-47, human OGDC-E2 100-113, and several peptides derived from various microbial proteins carrying an ExDK motif, whereas group B-cloned T-cell lines reacted only to E3BP 34-47 carrying an EIExD motif. Furthermore, an RGxG motif was exclusively found in the complementarity-determining region (CDR3) of the TCR Vbeta in the group B-cloned T-cell lines, while G, S, and/or R were frequently found in the CDR3 of the TCR Vbeta in the group A-cloned T-cell lines. These data provide a framework for understanding molecular mimicry among mitochondrial antigens."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.org/dc/terms/identifier | "doi:10.1053/jhep.2000.18714"xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Matsushita S."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Sakamoto N."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Ichiki Y."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Ishibashi H."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Shigematsu H."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Niho Y."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Gershwin M.E."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/author | "Shimoda S."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/name | "Hepatology"xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/pages | "901-909"xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/title | "Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens."xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/11050037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11050037 |
| http://purl.uniprot.org/citations/11050037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11050037 |
| http://purl.uniprot.org/uniprot/#_O00330-mappedCitation-11050037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11050037 |
| http://purl.uniprot.org/uniprot/O00330 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11050037 |