| http://purl.uniprot.org/citations/11051545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11051545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11051545 | http://www.w3.org/2000/01/rdf-schema#comment | "mRNA turnover mediated by the major protein-coding-region determinant of instability (mCRD) of the c-fos proto-oncogene transcript illustrates a functional interplay between mRNA turnover and translation. We show that the function of mCRD depends on its distance from the poly(A) tail. Five mCRD-associated proteins were identified: Unr, a purine-rich RNA binding protein; PABP, a poly(A) binding protein; PAIP-1, a poly(A) binding protein interacting protein; hnRNP D, an AU-rich element binding protein; and NSAP1, an hnRNP R-like protein. These proteins form a multiprotein complex. Overexpression of these proteins stabilized mCRD-containing mRNA by impeding deadenylation. We propose that a bridging complex forms between the poly(A) tail and the mCRD and ribosome transit disrupts or reorganizes the complex, leading to rapid RNA deadenylation and decay."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00102-1"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00102-1"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Chen C.-Y.A."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Chen C.-Y.A."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Shyu A.-B."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Shyu A.-B."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Grosset C."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Grosset C."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Jacquemin-Sablon H."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/author | "Jacquemin-Sablon H."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/pages | "29-40"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/pages | "29-40"xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/title | "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex."xsd:string |
| http://purl.uniprot.org/citations/11051545 | http://purl.uniprot.org/core/title | "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex."xsd:string |