| http://purl.uniprot.org/citations/11051553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11051553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11051553 | http://www.w3.org/2000/01/rdf-schema#comment | "In animal cells, duplication of centrosomes and DNA is coordinated. Since CDK2/cyclin E triggers initiation of both events, activation of CDK2/cyclin E is thought to link these two events. We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E in centrosome duplication. NPM/B23 associates specifically with unduplicated centrosomes, and NPM/B23 dissociates from centrosomes by CDK2/cyclin E-mediated phosphorylation. An anti-NPM/B23 antibody, which blocks this phosphorylation, suppresses the initiation of centrosome duplication in vivo. Moreover, expression of a nonphosphorylatable mutant NPM/ B23 in cells effectively blocks centrosome duplication. Thus, NPM/B23 is a target of CDK2/cyclin E in the initiation of centrosome duplication."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00093-3"xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00093-3"xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Chan P.K."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Chan P.K."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Okuda M."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Okuda M."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Bove K.E."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Bove K.E."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Fukasawa K."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Fukasawa K."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Tokuyama Y."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Tokuyama Y."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Smulian A.G."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Smulian A.G."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Hofmann I.A."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Hofmann I.A."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Horn H.F."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Horn H.F."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Knudsen E.S."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Knudsen E.S."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Snyder J.D."xsd:string |
| http://purl.uniprot.org/citations/11051553 | http://purl.uniprot.org/core/author | "Snyder J.D."xsd:string |