| http://purl.uniprot.org/citations/11053386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11053386 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11053386 | http://www.w3.org/2000/01/rdf-schema#comment | "The BTN1 gene product of the yeast Saccharomyces cerevisiae is 39% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. Furthermore, btn1-Delta strains have an elevated activity of the plasma membrane H(+)-ATPase due to an abnormally high vacuolar acidity during the early phase of growth. Previously, DNA microarray analysis revealed that btn1-Delta strains compensate for the altered plasma membrane H(+)-ATPase activity and vacuolar pH by elevating the expression of the two genes HSP30 and BTN2. We now show that deletion of either HSP30 or BTN2 in either BTN1(+) or btn1-Delta strains does not alter vacuolar pH but does lead to an increased activity of the vacuolar H(+)-ATPase. Deletion of BTN1, BTN2, or HSP30 does not alter cytosolic pH but diminishes pH buffering capacity and causes poor growth at low pH in a medium containing sorbic acid, a condition known to result in disturbed intracellular pH homeostasis. Btn2p was localized to the cytosol, suggesting a role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase. Increased expression of HSP30 and BTN2 in btn1-Delta strains and diminished growth of btn1-Delta, hsp30-Delta, and btn2-Delta strains at low pH reinforce our view that altered pH homeostasis is the underlying cause of Batten disease."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.182.22.6418-6423.2000"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.182.22.6418-6423.2000"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Sherman F."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Sherman F."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Pearce D.A."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Pearce D.A."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Chattopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Chattopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Muzaffar N.E."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/author | "Muzaffar N.E."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/pages | "6418-6423"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/pages | "6418-6423"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/title | "The yeast model for Batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/title | "The yeast model for Batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis."xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/11053386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11053386 |
| http://purl.uniprot.org/citations/11053386 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11053386 |