| http://purl.uniprot.org/citations/11057672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11057672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11057672 | http://www.w3.org/2000/01/rdf-schema#comment | "On antigen challenge, T-helper cells differentiate into two functionally distinct subsets, Th1 and Th2, characterized by the different effector cytokines that they secrete. Th1 cells produce interleukin (IL)-2, interferon-gamma (IFN-gamma) and lymphotoxin-beta, which mediate pro-inflammatory functions critical for the development of cell-mediated immune responses, whereas Th2 cells secrete cytokines such as IL-4, IL-5 and IL-10 that enhance humoral immunity. This process of T-helper cell differentiation is tightly regulated by cytokines. Here we report a new member of the type I cytokine receptor family, designated T-cell cytokine receptor (TCCR). When challenged in vivo with protein antigen, TCCR-deficient mice had impaired Th1 response as measured by IFN-gamma production. TCCR-deficient mice also had increased susceptibility to infection with an intracellular pathogen, Listeria monocytogenes. In addition, levels of antigen-specific immunoglobulin-gamma2a, which are dependent on Th1 cells, were markedly reduced in these mice. Our results demonstrate the existence of a new cytokine receptor involved in regulating the adaptive immune response and critical to the generation of a Th1 response."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.org/dc/terms/identifier | "doi:10.1038/35038103"xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.org/dc/terms/identifier | "doi:10.1038/35038103"xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Baker T."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Baker T."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Xie M.-H."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Xie M.-H."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Ghilardi N."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Ghilardi N."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Gurney A."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Gurney A."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "de Sauvage F.J."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "de Sauvage F.J."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Grewal I.S."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/author | "Grewal I.S."xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/11057672 | http://purl.uniprot.org/core/name | "Nature"xsd:string |