| http://purl.uniprot.org/citations/11067865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11067865 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-alpha-induced apoptosis is thought to involve mediators from acidic vesicles. Cathepsin B (cat B), a lysosomal cysteine protease, has recently been implicated in apoptosis. To determine whether cat B contributes to TNF-alpha-induced apoptosis, we exposed mouse hepatocytes to the cytokine in vitro and in vivo. Isolated hepatocytes treated with TNF-alpha in the presence of the transcription inhibitor actinomycin D (AcD) accumulated cat B in their cytosol. Further experiments using cell-free systems indicated that caspase-8 caused release of active cat B from purified lysosomes and that cat B, in turn, increased cytosol-induced release of cytochrome c from mitochondria. Consistent with these observations, the ability of TNF-alpha/AcD to induce mitochondrial release of cytochrome c, caspase activation, and apoptosis of isolated hepatocytes was markedly diminished in cells from CatB(-/-) mice. Deletion of the CatB gene resulted in diminished liver injury and enhanced survival after treatment in vivo with TNF-alpha and an adenovirus construct expressing the IkappaB superrepressor. Collectively, these observations suggest that caspase-mediated release of cat B from lysosomes enhances mitochondrial release of cytochrome c and subsequent caspase activation in TNF-alpha-treated hepatocytes."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci9914"xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Kaufmann S.H."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Miyoshi H."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Peters C."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Deussing J."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Svingen P.A."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Gores G.J."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Bronk S.F."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/author | "Guicciardi M.E."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/pages | "1127-1137"xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/title | "Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c."xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/11067865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11067865 |
| http://purl.uniprot.org/citations/11067865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11067865 |
| http://purl.uniprot.org/uniprot/#_P10605-mappedCitation-11067865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/#_Q3TC17-mappedCitation-11067865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/#_Q3TVS6-mappedCitation-11067865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/#_Q6LAF6-mappedCitation-11067865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/P10605 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/Q3TVS6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11067865 |
| http://purl.uniprot.org/uniprot/Q6LAF6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11067865 |