| http://purl.uniprot.org/citations/11067930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11067930 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-kappaB family of transcription factors are involved in the regulation of innate and adaptive immune functions associated with resistance to infection. To assess the role of NF-kappaB(2) in the regulation of cell-mediated immunity, mice deficient in the NF-kappaB(2) gene (NF-kappaB(2)(-/-)) were challenged with the intracellular parasite Toxoplasma gondii. Resistance to this opportunistic pathogen is dependent on the production of IL-12, which is required for the development of innate NK cell and adaptive T cell responses dominated by the production of IFN-gamma necessary to control replication of this parasite. Although wild-type controls were resistant to T. gondii, NF-kappaB(2)(-/-) mice developed severe toxoplasmic encephalitis and succumbed to disease between 3 and 10 wk following infection. However, NF-kappaB(2) was not required for the ability of macrophages to produce IL-12 or to inhibit parasite replication and during the acute stage of infection, NF-kappaB(2)(-/-) mice had no defect in their ability to produce IL-12 or IFN-gamma and infection-induced NK cell responses appeared normal. In contrast, during the chronic phase of the infection, susceptibility of NF-kappaB(2)(-/-) mice to toxoplasmic encephalitis was associated with a reduced capacity of their splenocytes to produce IFN-gamma associated with a loss of CD4(+) and CD8(+) T cells. This loss of T cells correlated with increased levels of apoptosis and with elevated expression of the pro-apoptotic molecule Fas by T cells from infected NF-kappaB(2)(-/-) mice. Together, these results suggest a role for NF-kappaB(2) in the regulation of lymphocyte apoptosis and a unique role for this transcription factor in maintenance of T cell responses required for long-term resistance to T. gondii."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.10.5720"xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Cai G."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Hunter C.A."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Craig L."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Caamano J."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Villegas E.N."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Alexander J."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Speirs K."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/author | "Tato C."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/pages | "5720-5728"xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/title | "Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii."xsd:string |
| http://purl.uniprot.org/citations/11067930 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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