| http://purl.uniprot.org/citations/11069838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11069838 | http://www.w3.org/2000/01/rdf-schema#comment | "Although lung transplantation is a widely applied therapeutic modality for end-stage pulmonary disease, the long-term survival following this procedure is limited by the development of bronchiolitis obliterans (BO). We investigated the role of RANTES, a C-C chemokine, in the evolution of fibrous airway obliteration (FAO) using a rat heterotopic tracheal transplant model. RANTES was highly expressed in infiltrating mononuclear cells in both allogeneic and isogeneic grafts as revealed by immunohistochemistry. Using a miniosmotic pump, neutralizing anti-RANTES antibody was locally and continuously infused to allografts, whereas recombinant rat RANTES was administered to isografts. Anti-RANTES antibody treatment decreased the number of CD4(+) infiltrating cells in allotracheas and preserved luminal patency compared with those of allocontrols. However, RANTES infusion in isografts did not induce FAO, even though CD4(+) cell migration was increased by this treatment. It appears that RANTES is relevant to the recruitment of CD4(+) cells and the development of FAO in the process of allorejection. Local administration of anti-RANTES might be a therapeutic option for BO following lung transplantation."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.org/dc/terms/identifier | "doi:10.1164/ajrccm.162.5.9910082"xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Fischer S."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Liu M."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Keshavjee S."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Suga M."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Moreira J.M."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/author | "Maclean A.A."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/name | "Am J Respir Crit Care Med"xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/pages | "1940-1948"xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/title | "RANTES plays an important role in the evolution of allograft transplant-induced fibrous airway obliteration."xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/11069838 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11069838 |
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