| http://purl.uniprot.org/citations/11073960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11073960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11073960 | http://www.w3.org/2000/01/rdf-schema#comment | "HIC-1 (hypermethylated in cancer 1), a BTB/POZ transcriptional repressor, was isolated as a candidate tumor suppressor gene located at 17p13.3, a region hypermethylated or subject to allelic loss in many human cancers and in the Miller-Dieker syndrome. The human HIC-1 gene is composed of two exons, a short 5'-untranslated exon and a large second coding exon. Recently, two murine HIC-1 isoforms generated by alternative splicing have been described. To determine whether such isoforms also exist in human, we have further analyzed the human HIC-1 locus. Here, we describe and extensively characterize a novel alternative noncoding upstream exon, exon 1b, associated with a major GC-rich promoter. We demonstrate using functional assays that the murine exon 1b previously described as coding from computer analyses of genomic sequences is in fact a noncoding exon highly homologous to its human counterpart. In addition, we report that the human untranslated exon is presumably a coding exon, renamed exon 1a, both in mice and humans. Both types of transcripts are detected in various normal human tissues with a predominance for exon 1b containing transcripts and are up-regulated by TP53, confirming that HIC-1 is a TP53 target gene. Thus, HIC-1 function in the cell is controlled by a complex interplay of transcriptional and translational regulation, which could be differently affected in many human cancers."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008690200"xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m008690200"xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Godwin A.K."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Godwin A.K."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Leprince D."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Leprince D."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Begue A."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Begue A."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Monte D."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Monte D."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Deltour S."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Deltour S."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Guerardel C."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Guerardel C."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Pinte S."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/author | "Pinte S."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/pages | "3078-3089"xsd:string |
| http://purl.uniprot.org/citations/11073960 | http://purl.uniprot.org/core/pages | "3078-3089"xsd:string |