| http://purl.uniprot.org/citations/11076762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11076762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11076762 | http://www.w3.org/2000/01/rdf-schema#comment | "bHLH transcription factors function in neuronal development in organisms as diverse as worms and vertebrates. In the C. elegans male tail, a neuronal sublineage clonally gives rise to the three cell types (two neurons and a structural cell) of each sensory ray. We show here that the bHLH genes lin-32 and hlh-2 are necessary for the specification of multiple cell fates within this sublineage, and for the proper elaboration of differentiated cell characteristics. Mutations in lin-32, a member of the atonal family, can cause failures at each of these steps, resulting in the formation of rays that lack fully-differentiated neurons, neurons that lack cognate rays, and ray cells defective in the number and morphology of their processes. Mutations in hlh-2, the gene encoding the C. elegans E/daughterless ortholog, enhance the ray defects caused by lin-32 mutations. In vitro, LIN-32 can heterodimerize with HLH-2 and bind to an E-box-containing probe. Mutations in these genes interfere with this activity in a manner consistent with the degree of ray defects observed in vivo. We propose that LIN-32 and HLH-2 function as a heterodimer to activate different sets of targets, at multiple steps in the ray sublineage. During ray development, lin-32 performs roles of proneural, neuronal precursor, and differentiation genes of other systems."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.24.5415"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.127.24.5415"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/author | "Portman D.S."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/author | "Portman D.S."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/author | "Emmons S.W."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/author | "Emmons S.W."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/pages | "5415-5426"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/pages | "5415-5426"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/title | "The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/title | "The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage."xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/11076762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11076762 |
| http://purl.uniprot.org/citations/11076762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11076762 |
| http://purl.uniprot.org/citations/11076762 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11076762 |
| http://purl.uniprot.org/citations/11076762 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11076762 |
| http://purl.uniprot.org/uniprot/Q10574 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11076762 |
| http://purl.uniprot.org/uniprot/G5EEG9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11076762 |