| http://purl.uniprot.org/citations/11076973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11076973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11076973 | http://www.w3.org/2000/01/rdf-schema#comment | "Drosophila cellularization and animal cell cytokinesis rely on the coordinated functions of the microfilament and microtubule cytoskeletal systems. To identify new proteins involved in cellularization and cytokinesis, we have conducted a biochemical screen for microfilament/microtubule-associated proteins (MMAPs). 17 MMAPs were identified; seven have been previously implicated in cellularization and/or cytokinesis, including KLP3A, Anillin, Septins, and Dynamin. We now show that a novel MMAP, Lava Lamp (Lva), is also required for cellularization. Lva is a coiled-coil protein and, unlike other proteins previously implicated in cellularization or cytokinesis, it is Golgi associated. Our functional analysis shows that cellularization is dramatically inhibited upon injecting anti-Lva antibodies (IgG and Fab) into embryos. In addition, we show that brefeldin A, a potent inhibitor of membrane trafficking, also inhibits cellularization. Biochemical analysis demonstrates that Lva physically interacts with the MMAPs Spectrin and CLIP190. We suggest that Lva and Spectrin may form a Golgi-based scaffold that mediates the interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization. Our results are consistent with the idea that animal cell cytokinesis depends on both actomyosin-based contraction and Golgi-derived membrane secretion."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.151.4.905"xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.151.4.905"xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Field C."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Field C."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Ventura R."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Ventura R."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Sullivan W."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Sullivan W."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Royou A."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Royou A."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Sisson J.C."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/author | "Sisson J.C."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/pages | "905-918"xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/pages | "905-918"xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/title | "Lava lamp, a novel peripheral Golgi protein, is required for Drosophila melanogaster cellularization."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/title | "Lava lamp, a novel peripheral Golgi protein, is required for Drosophila melanogaster cellularization."xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/volume | "151"xsd:string |
| http://purl.uniprot.org/citations/11076973 | http://purl.uniprot.org/core/volume | "151"xsd:string |