| http://purl.uniprot.org/citations/11079376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11079376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11079376 | http://www.w3.org/2000/01/rdf-schema#comment | "Complete cDNAs for the fast-twitch Ca2+ -ATPase isoform (SERCA 1) were cloned and sequenced from blue marlin (Makaira nigricans) extraocular muscle (EOM). Complete cDNAs for SERCA 1 were also cloned from fast-twitch skeletal muscle of the same species. The two sequences are identical over the coding region except for the last five codons on the carboxyl end; EOM SERCA 1 cDNA codes for 996 amino acids and the fast-twitch cDNAs code for 991 aa. Phylogenetic analysis revealed that EOM SERCA 1 clusters with an isoform of Ca2+ -ATPase normally expressed in early development of mammals (SERCA 1B). This is the first report of SERCA 1B in an adult vertebrate. RNA hybridization assays indicate that 1B expression is limited to extraocular muscles. Because EOM gives rise to the thermogenic heater organ in marlin, we investigated whether SERCA 1B may play a role in heat generation, or if 1B expression is common in EOM among vertebrates. Chicken also expresses SERCA 1B in EOM, but rat expresses SERCA 1A; because SERCA 1B is not specific to heater tissue we conclude it is unlikely that it plays a specific role in intracellular heat production. Comparative sequence analysis does reveal, however, several sites that may be the source of functional differences between fish and mammalian SERCAs."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0305-0491(00)00256-x"xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0305-0491(00)00256-x"xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Block B.A."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Block B.A."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Cramer T.D."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Cramer T.D."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Franck J.P.C.F."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Franck J.P.C.F."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Londraville R.L."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Londraville R.L."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Tullis A."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/author | "Tullis A."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/name | "Comp. Biochem. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/name | "Comp. Biochem. Physiol."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/pages | "223-233"xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/pages | "223-233"xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/title | "Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans)."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/title | "Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans)."xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/volume | "127B"xsd:string |
| http://purl.uniprot.org/citations/11079376 | http://purl.uniprot.org/core/volume | "127B"xsd:string |