| http://purl.uniprot.org/citations/11081633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11081633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11081633 | http://www.w3.org/2000/01/rdf-schema#comment | "P-, E- and L-selectin constitute a family of cell adhesion receptors that mediate the initial tethering and rolling of leukocytes on inflamed endothelium as a prelude to their firm attachment and extravasation into tissues. The selectins bind weakly to sialyl Lewisx (SLe(X))-like glycans, but with high-affinity to specific glycoprotein counterreceptors, including PSGL-1. Here, we report crystal structures of human P- and E-selectin constructs containing the lectin and EGF (LE) domains co-complexed with SLe(X). We also present the crystal structure of P-selectin LE co-complexed with the N-terminal domain of human PSGL-1 modified by both tyrosine sulfation and SLe(X). These structures reveal differences in how E- and P-selectin bind SLe(X) and the molecular basis of the high-affinity interaction between P-selectin and PSGL-1."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00138-0"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)00138-0"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Somers W.S."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Somers W.S."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Camphausen R.T."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Camphausen R.T."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Shaw G.D."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/author | "Shaw G.D."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/pages | "467-479"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/pages | "467-479"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/title | "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/title | "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/11081633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11081633 |
| http://purl.uniprot.org/citations/11081633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11081633 |