| http://purl.uniprot.org/citations/11085512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11085512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11085512 | http://www.w3.org/2000/01/rdf-schema#comment | "TCF transcription factors are mediators of the WNT signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. Here human TCF-3 has been cloned and characterized. Differential expression analyses of TCF genes in gastric cancer revealed that TCF-1 was expressed in most cases of primary gastric cancer at almost the same level as in normal gastric mucosa and that TCF-3 was occasionally up-regulated in primary gastric cancer. The TCF-3 expression vector was transfected to gastric cancer cell line MKN28 to establish stable transformants. Three independent MKN28 transformants overexpressing TCF-3 showed about 8-fold resistance to mitomycin C (MMC; IC50, 2.4 microg/ml) compared with MKN28 vector transfectants (IC50 = 0.3 microg/ml). Among the 10 drug resistance-associated genes examined in this study, the DT-diaphorase (DTD) gene was down-regulated in three MKN28 transformants overexpressing TCF-3. DTD mRNA was also down-regulated in primary gastric cancer with TCF-3 up-regulation. In addition, DTD protein was down-regulated in three MKN28 transformants overexpressing TCF-3 compared with MKN28 vector transfectants. DTD is implicated in the activation of MMC in target cells, and DTD down-regulation explains MMC resistance. MMC resistance induced by TCF-3 overexpression is probably due to DTD down-regulation, which might provide a possible target for new therapy of drug-resistant gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/author | "Katoh M."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/author | "Katoh M."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/author | "Sagara N."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/author | "Sagara N."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/pages | "5959-5962"xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/pages | "5959-5962"xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/title | "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/title | "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation."xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://purl.uniprot.org/core/volume | "60"xsd:string |
| http://purl.uniprot.org/citations/11085512 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11085512 |
| http://purl.uniprot.org/citations/11085512 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11085512 |
| http://purl.uniprot.org/citations/11085512 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11085512 |
| http://purl.uniprot.org/citations/11085512 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11085512 |
| http://purl.uniprot.org/uniprot/Q9HCS4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11085512 |
| http://purl.uniprot.org/uniprot/#_kb.Q9HCS4_up.isolatedFrom_tissue.345 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11085512 |
| http://purl.uniprot.org/uniprot/Q9HCS4#attribution-4FD6C27607DCD88F5B9D13A6B29DD02F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11085512 |
| http://purl.uniprot.org/uniprot/#_Q9HCS4-citation-11085512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11085512 |