| http://purl.uniprot.org/citations/11086082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11086082 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophage inflammatory protein-1alpha (MIP-1alpha/CCL3) is a CC chemokine required for optimal recruitment of leukocytes in response to cryptococcal Ags. MIP-1alpha is expressed in the lungs by day 6 post Cryptococcus neoformans infection and could play a role in the development of cell-mediated immunity. To address this possibility, wild-type (MIP-1alpha(+/+)) mice and MIP-1alpha knockout (MIP-1alpha(-/-)) mice were infected intratracheally with a highly virulent strain of C. neoformans (145A). MIP-1alpha message was detected in the lungs on days 3, 7, and 14 in MIP-1alpha(+/+) mice, but it was undetectable in MIP-1alpha(-/-) mice. On day 16, MIP-1alpha(-/-) mice had a 7-fold increase in C. neoformans burden in the lungs, but no decrease in pulmonary leukocyte recruitment. MIP-1alpha(+/+) and MIP-1alpha(-/-) mice had similar numbers of recruited lymphocytes and monocytes/macrophages. Notably, MIP-1alpha(-/-) mice had a significantly greater number of eosinophils. MIP-1alpha(-/-) mice had extremely high levels of serum IgE. This switch of immune response to a T(2) phenotype was associated with enhanced IL-4 and IL-13 expression in the lungs of MIP-1alpha(-/-) mice compared with MIP-1alpha (+/+) mice. Progression of pulmonary cryptococcosis in the presence of nonprotective T(2) immunity resulted in profound lung damage in MIP-1alpha(-/-) mice (eosinophilic crystal deposition, destruction of lung parenchyma, and pulmonary hemorrhage). Twelve-week survival was dramatically decreased in MIP-1alpha(-/-) mice. These studies, together with our previous studies, demonstrate that MIP-1alpha plays a role in both the afferent (T(1)/T(2) development) and efferent (T(1)-mediated leukocyte recruitment) phases of cell-mediated immunity to C. neoformans."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.165.11.6429"xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Cook D.N."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Olszewski M.A."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Huffnagle G.B."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Lindell D.M."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "McDonald R.A."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Toews G.B."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/author | "Moore B.B."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/pages | "6429-6436"xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/title | "The role of macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection."xsd:string |
| http://purl.uniprot.org/citations/11086082 | http://purl.uniprot.org/core/volume | "165"xsd:string |
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