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| http://purl.uniprot.org/citations/11090880 | http://www.w3.org/2000/01/rdf-schema#comment | "This study analyzes the gene repertoire coding for antibodies to an evolutionary novel immunogenic carbohydrate antigen in mice. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (KO) mice, where it can induce the production of the anti-Gal antibody. Hybridoma clones secreting anti-Gal were isolated from different mice and their immunoglobulin genes were analyzed. All anti-Gal clones were found to be encoded by the heavy chain gene VH22.1 and light chain gene VK5.1. Moreover, one 'forbidden' anti-Gal clone, produced in a wild type mouse, was also encoded by VH 22.1 and VK 5.1. The genes coding for the different anti-Gal clones were found to contain somatic mutations and different CDR3 domains. These data imply that a highly restricted gene usage combined with junctional diversity and somatic mutations can generate new antibodies that have not been produced in the course of the evolution of a species."xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0161-5890(00)00064-x"xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/author | "Chen Z.C."xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/author | "Galili U."xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/author | "Radic M.Z."xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/pages | "455-466"xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/title | "Genes coding evolutionary novel anti-carbohydrate antibodies: studies on anti-Gal production in alpha 1,3galactosyltransferase knock out mice."xsd:string |
| http://purl.uniprot.org/citations/11090880 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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