| http://purl.uniprot.org/citations/11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11092520 | http://www.w3.org/2000/01/rdf-schema#comment | "Given that the NcoI polymorphism of the tumor necrosis factor-beta (TNF-beta) gene has been shown to be associated with tumor necrosis factor-alpha (TNF-alpha) secretory capacity, we know that this TNF-beta gene polymorphism may influence insulin resistance. In Caucasians, 2 polymorphisms of the TNF-alpha promoter region (positions -308 and -238) have been reported to be associated with insulin resistance. Thus, we investigated how genetic variation in the TNF-beta and TNF-alpha genes was associated with insulin resistance in 211 Japanese men. The frequency of the TNF-beta gene polymorphism was 0.41, and insulin resistance, estimated by homeostasis model assessment (HOMA), was significantly lower in variant homozygotes versus wild-type allele. The frequencies of the -308 and -238 polymorphisms were 0.01 and 0.02, respectively, and these polymorphisms were not associated with insulin resistance. Our results suggest that the TNF-beta gene polymorphism decreases insulin resistance, and that the -308 and -238 polymorphisms of the TNF-alpha promoter region are not a major contributing factor to insulin resistance in Japanese men."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.org/dc/terms/identifier | "doi:10.1053/meta.2000.17710"xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Hayakawa T."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Nagai Y."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Yamashita H."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Kobayashi K."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Takamura T."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/author | "Nomura G."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/name | "Metabolism"xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/pages | "1506-1509"xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men."xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/11092520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11092520 |
| http://purl.uniprot.org/citations/11092520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7Z3-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A286SD60-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A286SD61-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |
| http://purl.uniprot.org/uniprot/#_A0A286SD62-mappedCitation-11092520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11092520 |