| http://purl.uniprot.org/citations/11094164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11094164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11094164 | http://www.w3.org/2000/01/rdf-schema#comment | "A putative guanine nucleotide exchange factor (GEF), termed leukemia-associated RhoGEF (LARG), was recently identified upon fusion to the coding sequence of the MLL gene in acute myeloid leukemia. Although the function of LARG is still unknown, it exhibits a number of structural domains suggestive of a role in signal transduction, including a PDZ domain, a LH/RGS domain, and a Dbl homology/pleckstrin homology domain. Here, we show that LARG can activate Rho in vivo. Furthermore, we present evidence that LARG is an integral component of a novel biochemical route whereby G protein-coupled receptors (GPCRs) and heterotrimeric G proteins of the G alpha(12) family stimulate Rho-dependent signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)02224-9"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(00)02224-9"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Chikumi H."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/author | "Chikumi H."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/pages | "183-188"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/pages | "183-188"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/title | "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/title | "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho."xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/volume | "485"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://purl.uniprot.org/core/volume | "485"xsd:string |
| http://purl.uniprot.org/citations/11094164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11094164 |
| http://purl.uniprot.org/citations/11094164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11094164 |
| http://purl.uniprot.org/citations/11094164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11094164 |
| http://purl.uniprot.org/citations/11094164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11094164 |