RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/11095967http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11095967http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11095967http://www.w3.org/2000/01/rdf-schema#comment"A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a "Zn-hand" domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3p21.3."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2000.3870"xsd:string
http://purl.uniprot.org/citations/11095967http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.2000.3870"xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Nakamura A."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Nakamura A."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Shimizu K."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Shimizu K."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Shimizu N."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Shimizu N."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Sakai A."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Sakai A."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Ouchida M."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Ouchida M."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Tsukuda K."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Tsukuda K."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Toyooka S."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Toyooka S."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Jitsumori Y."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/author"Jitsumori Y."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/date"2000"xsd:gYear
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/11095967http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string