| http://purl.uniprot.org/citations/11096118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11096118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11096118 | http://www.w3.org/2000/01/rdf-schema#comment | "The IL-1 receptor-associated kinase (IRAK/mPLK) is linked to the regulation of nuclear factor-kappaB (NF-kappaB)-dependent gene expression. Here we describe a novel binding partner of IRAK/mPLK that we term SIMPL (signaling molecule that associates with the mouse pelle-like kinase). Overexpression of SIMPL leads to the activation of NF-kappaB-dependent promoters, and inactivation of SIMPL inhibits IRAK/mPLK as well as tumor necrosis factor receptor type I-induced NF-kappaB activity. Dominant inhibitory alleles of IkappaB kinase (IKKalpha or IKKbeta) block the activation of NF-kappaB by IRAK/mPLK and SIMPL. Furthermore, SIMPL binds IRAK/mPLK and the IKKs in vitro and in vivo. In the presence of antisense mRNA to SIMPL, the physical association between IRAK/mPLK and IKKbeta but not IRAK/mPLK and IKKalpha is greatly diminished. Moreover, dominant-negative SIMPL blocks IKKalpha- or IKKbeta-induced NF-kappaB activity. These results lead us to propose a model in which SIMPL functions to regulate NF-kappaB activity by linking IRAK/mPLK to IKKbeta/alpha-containing complexes."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m010399200"xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m010399200"xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Harrington M.A."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Harrington M.A."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Green M."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Green M."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Goebl M.G."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Goebl M.G."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Kwon H.-J."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Kwon H.-J."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Vig E."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Vig E."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Yu K.-Y."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/author | "Yu K.-Y."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11096118 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |