| http://purl.uniprot.org/citations/11098934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11098934 | http://www.w3.org/2000/01/rdf-schema#comment | "Norwegian babies born with the HLA-DRB1*0401-DQA1*03-DQB1*0302/DRB1*03-DQA1+ ++*05-DQB1*0201 genotype have an estimated 17% lifetime risk of developing insulin-dependent diabetes mellitus (IDDM). Identifying these children is important for future prevention, and for studies of the non-genetic factors involved in IDDM. The aim of the study was to develop a rapid screening method for this high-risk genotype. DNA was extracted from serum collected during routine newborn screening for phenylketonuria and hypothyreosis. The second exons of HLA-DQA1 and DQB1 were co-amplified using biotinylated primers, amplicons were hybridized to a set of seven probes immobilized on a microtitre plate using a single hybridisation temperature, and detected colorimetrically by streptavidin-HRP conjugate and tetramethylbenzidine substrate. The DRB1*04 subtyping was performed using six different probes at identical conditions. The prevalence of the DRB1*0401-DQA1*03-DQB1*0302/DRB1*03-DQA1*0 5-DQB1*0201 genotype among 1,026 Norwegian babies was 2.7% (CI 95%: 1.7-3.7%). The new high-throughput genetic screening method for IDDM risk can easily be automated and included in newborn screening programs."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.org/dc/terms/identifier | "doi:10.1034/j.1399-0039.2000.560406.x"xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Wilkinson E."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Ronningen K.S."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Cinek O."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Saugstad O.D."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Magnus P."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/author | "Paltiel L."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/pages | "344-349"xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/title | "Screening for the IDDM high-risk genotype. A rapid microtitre plate method using serum as source of DNA."xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/11098934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11098934 |
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