| http://purl.uniprot.org/citations/11101512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11101512 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11101512 | http://www.w3.org/2000/01/rdf-schema#comment | "Tim8 and Tim13 are non-essential, conserved proteins of the mitochondrial intermembrane space, which are organized in a hetero-oligomeric complex. They are structurally related to Tim9 and Tim10, essential components of the import machinery for mitochondrial carrier proteins. Here we show that the TIM8-13 complex interacts with translocation intermediates of Tim23, which are partially translocated across the outer membrane but not with fully imported or assembled Tim23. The TIM8-13 complex binds to the N-terminal or intermediate domain of Tim23. It traps the incoming precursor in the intermembrane space thereby preventing retrograde translocation. The TIM8-13 complex is strictly required for import of Tim23 under conditions when a low membrane potential exists in the mitochondria. The human homologue of Tim8 is encoded by the DDP1 (deafness/dystonia peptide 1) gene, which is associated with the Mohr-Tranebjaerg syndrome (MTS), a progressive neurodegenerative disorder leading to deafness. It is demonstrated that import of human Tim23 is dependent on a high membrane potential. A mechanism to explain the pathology of MTS is discussed."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.23.6392"xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.23.6392"xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Neupert W."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Neupert W."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Bauer M.F."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Bauer M.F."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Brunner M."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Brunner M."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Paschen S.A."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Paschen S.A."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Kaldi K."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Kaldi K."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Rothbauer U."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/author | "Rothbauer U."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/pages | "6392-6400"xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/pages | "6392-6400"xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/title | "The role of the TIM8-13 complex in the import of Tim23 into mitochondria."xsd:string |
| http://purl.uniprot.org/citations/11101512 | http://purl.uniprot.org/core/title | "The role of the TIM8-13 complex in the import of Tim23 into mitochondria."xsd:string |