| http://purl.uniprot.org/citations/11101638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11101638 | http://www.w3.org/2000/01/rdf-schema#comment | "The high-affinity IgE receptor (FcepsilonRI) on mast cells and basophils consists of a ligand-binding alpha-chain and two kinds of signaling chains, a beta-chain and disulfide-linked homodimeric gamma-chains. Crosslinking by multivalent antigen results in the aggregation of the bound IgE/alpha-chain complexes at the cell surface, triggering cell activation, and subsequent internalization through coated pits. However, the precise topographical alterations of the signaling beta- and gamma-chains during stimulation remain unclarified despite their importance in ligand binding/signaling coupling. Here we describe the dynamics of FcepsilonRI subunit distribution in rat basophilic leukemia cells during stimulation as revealed by immunofluorescence and immunogold electron microscopy. Immunolocalization of beta- and gamma-chains was homogeneously distributed on the cell surfaces before stimulation, while crosslinking with multivalent antigen, which elicited optimal degranulation, caused a distinct aggregation of these signaling chains on the cell membrane. Moreover, only gamma-but not beta-chains were aggregated during the stimulation that evoked suboptimal secretion. These findings suggest that high-affinity IgE receptor beta- and gamma-chains do not co-aggregate but for the most part form homogenous aggregates of beta-chains or gamma-chains after crosslinking."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.org/dc/terms/identifier | "doi:10.1177/002215540004801213"xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Asai K."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Ide C."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Ra C."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Kusunoki T."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Harazaki M."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Hosoi S."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/author | "Korematsu S."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/name | "J Histochem Cytochem"xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/pages | "1705-1716"xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/title | "Distinct aggregation of beta- and gamma-chains of the high-affinity IgE receptor on cross-linking."xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/11101638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11101638 |
| http://purl.uniprot.org/citations/11101638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11101638 |
| http://purl.uniprot.org/uniprot/P13386#attribution-E4475734799E1A07308F49E1135B0C11 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/#_A0A0H2UHS6-mappedCitation-11101638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/#_A0A8A1UDV7-mappedCitation-11101638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/#_P13386-mappedCitation-11101638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/A0A0H2UHS6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/A0A8A1UDV7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11101638 |
| http://purl.uniprot.org/uniprot/P13386 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11101638 |