| http://purl.uniprot.org/citations/11101887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11101887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11101887 | http://www.w3.org/2000/01/rdf-schema#comment | "Many proteins contain targeting signals within their sequences that specify their delivery to particular organelles. The peroxisomal targeting signal-1 (PTS1) is a C-terminal tripeptide that is sufficient to direct proteins into peroxisomes. The PTS1 sequence closely approximates Ser-Lys-Leu-COO-. PEX5, the receptor for PTS1, interacts with the signal via a series of tetratricopeptide repeats (TPRs) within its C-terminal half. Here we report the crystal structure of a fragment of human PEX5 that includes all seven predicted TPR motifs in complex with a pentapeptide containing a PTS1 sequence. Two clusters of three TPRs almost completely surround the peptide, while a hinge region, previously identified as TPR4, forms a distinct structure that enables the two sets of TPRs to form a single binding site. This structure reveals the molecular basis for PTS1 recognition and demonstrates a novel mode of TPR-peptide interaction."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.org/dc/terms/identifier | "doi:10.1038/81930"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.org/dc/terms/identifier | "doi:10.1038/81930"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Gatto G.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Gatto G.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Gould S.J."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Gould S.J."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Berg J.M."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/author | "Berg J.M."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/name | "Nat. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/pages | "1091-1095"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/pages | "1091-1095"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/title | "Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/title | "Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5."xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/11101887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11101887 |
| http://purl.uniprot.org/citations/11101887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11101887 |