| http://purl.uniprot.org/citations/11112704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11112704 | http://www.w3.org/2000/01/rdf-schema#comment | "In the budding yeast Saccharomyces cerevisiae, a prospective mother normally commences the formation of a daughter (the bud) only in the G(1) phase of the cell division cycle. This suggests a strict temporal regulation of the processes that initiate the formation of a new bud. Using cortical localization of bud site components Spa2 and Bni1 as an indicator of bud site assembly, we show that cells assemble a bud site following inactivation of the Cdc28-Clb mitotic kinase but prior to START. Interestingly, an untimely inactivation of the mitotic kinase is sufficient to drive cells to assemble a new bud site inappropriately in G(2) or M phases. The induction of Cdc28/Clb kinase activity in G(1), on the other hand, dramatically reduces a cell's ability to construct an incipient bud site. Our findings strongly suggest that the Cdc28-Clb kinase plays a critical role in the mechanism that restricts the timing of bud formation to the G(1) phase of the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.114.1.207"xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/author | "Surana U."xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/author | "Padmashree C.G."xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/pages | "207-218"xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/title | "Cdc28-Clb mitotic kinase negatively regulates bud site assembly in the budding yeast."xsd:string |
| http://purl.uniprot.org/citations/11112704 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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