| http://purl.uniprot.org/citations/11114305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11114305 | http://www.w3.org/2000/01/rdf-schema#comment | "LAP/C/EBPbeta is a member of the C/EBP family of transcription factors and contributes to the regulation of the acute phase response in hepatocytes. Here we show that IL-6 controls LAP/C/EBPbeta gene transcription and identify an IL-6 responsive element in the LAP/C/EBPbeta promoter, which contains no STAT3 DNA binding motif. However, luciferase reporter gene assays showed that STAT3 activation through the gp130 signal transducer molecule is involved in mediating IL-6-dependent LAP/C/EBPbeta transcription. Southwestern analysis indicated that IL-6 induces binding of a 68-kDa protein to the recently characterized CRE-like elements in the LAP/C/EBPbeta promoter. Transfection experiments using promoter constructs with mutated CRE-like elements revealed that these sites confer IL-6 responsiveness. Further analysis using STAT1/STAT3 chimeras identified specific domains of the protein that are required for the IL-6-dependent increase in LAP/C/EBPbeta gene transcription. Overexpression of the amino-terminal domain of STAT3 blocked the IL-6-mediated response, suggesting that the STAT3 amino terminus has an important function in IL-6-mediated transcription of the LAP/C/EBPbeta gene. These data lead to a model of how tethering STAT3 to a DNA-bound complex contributes to IL-6-dependent LAP/C/EBPbeta gene transcription. Our analysis describes a new mechanism by which STAT3 controls gene transcription and which has direct implication for the acute phase response in liver cells."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m009284200"xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Trautwein C."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Manns M.P."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Horn F."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Bischoff S.C."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Niehof M."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Rakemann T."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/author | "Streetz K."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/pages | "9016-9027"xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/title | "Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3."xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11114305 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11114305 |
| http://purl.uniprot.org/citations/11114305 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11114305 |
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| http://purl.uniprot.org/uniprot/#_P05231-mappedCitation-11114305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11114305 |
| http://purl.uniprot.org/uniprot/#_P30260-mappedCitation-11114305 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11114305 |