| http://purl.uniprot.org/citations/11116112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11116112 | http://www.w3.org/2000/01/rdf-schema#comment | "In polygenetic disorders, such as ischemic heart disease, the investigation of gene-gene interactions rather than determination of single gene effects is crucial to better understand the contribution of genetic factors. The 825T allele of the G-protein ss(3)-subunit gene (GNB3) associated with enhanced G-protein signaling is a candidate to interact with the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism to increase the risk for myocardial infarction (MI). The ACE D:/I variant affects the renin-angiotensin system hormones that activate G-protein-coupled receptors. Genotyping at the ACE and GNB3 loci was performed on 585 patients with coronary artery disease with (n=270) or without (n=315) previous MI. Logistic regression analysis demonstrated a significant interaction between the ACE D: allele and the GNB3 825T allele (P<0.001). The odds ratio for MI, associated with the 825T allele, was not increased in the presence of the ACE II genotype (OR 0.5; P=0.09) but was significantly higher in 825T allele carriers with the ACE DI genotype (OR 1.9; P=0.01) and further increased in individuals with the ACE DD genotype (OR 2.4; P=0.02). The highest odds ratio was found in homozygous 825T allele carriers with the ACE DD genotype (OR 7.5; P=0.006). Our data suggest a significant interaction of the GNB3 825T allele with the ACE D allele in MI. These hypothesis-generating data may justify larger prospective studies."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.hyp.36.6.986"xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/author | "Siffert W."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/author | "Erbel R."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/author | "Husing J."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/author | "Naber C.K."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/author | "Wolfhard U."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/pages | "986-989"xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/title | "Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction."xsd:string |
| http://purl.uniprot.org/citations/11116112 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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