| http://purl.uniprot.org/citations/11116209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11116209 | http://www.w3.org/2000/01/rdf-schema#comment | "We have studied the effects of a cardiac sparing thyromimetic, CGS 23425, on postprandial levels of triglycerides, abundance of apolipoprotein B (apo B) protein and hepatic apo B mRNA expression in rats. When compared with control rats, triglyceride clearance was significantly accelerated by treatment with CGS 23425. A full return to baseline values was achieved within 8 h after ingesting a large quantity of fat, as compared to >24 h in control animals. The abundance of apo B-100 protein in CGS 23425-treated hyperlipidemic rats decreased in a dose-dependent manner, but levels of apo B-48 were not significantly affected. Like L-tri-iodothyronine (L-T(3)), treatment with 30 microg/kg CGS 23425 for 6 or 9 days decreased the levels of apo B-100 protein by 80% and 40% respectively. This change was paralleled by a 27% reduction in hepatic apo B-100 mRNA. To investigate a potential mechanism of CGS 23425 action, we measured in vitro apo B mRNA editing activity in hepatocellular extract from control or CGS 23425-treated rats. Treatment with CGS 23425 increased activity of the hepatic apo B-100 editosome, apobec-1. In human hepatoma cells which lack apobec-1 activity, apo B-100 mRNA levels remained the same in cells treated with or without the agent. In summary, these observations show that CGS 23425 decreases the levels of apo B-100 in rats. This action of CGS 23425 involves apo B-100 mRNA editing activity."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.org/dc/terms/identifier | "doi:10.1677/jme.0.0250299"xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Steele R.E."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Wada Y."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Dufresne J."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Matsubara S."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Wong N.C."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Hargrove G.M."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/author | "Stephan Z.F."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/name | "J Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/pages | "299-308"xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/title | "Effects of a thyromimetic on apolipoprotein B-100 in rats."xsd:string |
| http://purl.uniprot.org/citations/11116209 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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