| http://purl.uniprot.org/citations/11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11118029 | http://www.w3.org/2000/01/rdf-schema#comment | "Several studies provide evidence that in addition to the DQ-DR genes, HLA contains another uncharacterized gene or genes associated with type 1 diabetes. Our aim was to investigate the effect of this gene independently of the DQ-DR genes and to localize it with a matched case-control study. More than 1,400 patients and 30,000 control individuals from Finland were studied. They were first genotyped for the selected alleles of the HLA-DQB1, -DQA1, and -DRB1 genes. For the DR3/4(0404) genotype, 75 patients and 181 control subjects were stratified, and 241 patients and 354 controls were stratified for the DR3/4(0401) genotype. Ten microsatellite markers in the HLA class III and I regions (D6S273, TNFa, C12A, STR MICA, MIB, C125, C143, C245, C3211, and MOGc) and selected alleles of the HLA-A and HLA-B genes were studied. In the DR3/4(0404)-stratified group, we found that markers located between C12A and C143 near the HLA-B gene confer a strong additional diabetes association. This was confirmed by the population differentiation test in both DR3/4(0404)- and DR3/4(0401)-stratified groups. Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.org/dc/terms/identifier | "doi:10.2337/diabetes.49.12.2217"xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Gombos Z."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Knip M."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Nejentsev S."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Vaarala O."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Simell O."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Ilonen J."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Akerblom H.K."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Laine A.P."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/author | "Veijola R."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/pages | "2217-2221"xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/title | "Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B."xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/11118029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11118029 |
| http://purl.uniprot.org/citations/11118029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-11118029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11118029 |