| http://purl.uniprot.org/citations/11118202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11118202 | http://www.w3.org/2000/01/rdf-schema#comment | "Repair of DNA damage by homologous recombination has only recently been established as an important mechanism in maintaining genetic stability in mammalian cells. The recently cloned Xrcc2 gene is a member of the mammalian Rad51 gene family, thought to be central to homologous recombination repair. To understand its function in mammals, we have disrupted Xrcc2 in mice. No Xrcc2(-/-) animals were found alive, with embryonic lethality occurring from mid-gestation. Xrcc2(-/-) embryos surviving until later stages of embryogenesis commonly showed developmental abnormalities and died at birth. Neonatal lethality, apparently due to respiratory failure, was associated with a high frequency of apoptotic death of post-mitotic neurons in the developing brain, leading to abnormal cortical structure. Embryonic cells showed genetic instability, revealed by a high level of chromosomal aberrations, and were sensitive to gamma-rays. Our findings demonstrate that homologous recombination has an important role in endogenous damage repair in the developing embryo. Xrcc2 disruption identifies a range of defects that arise from malfunction of this repair pathway, and establishes a previously unidentified role for homologous recombination repair in correct neuronal development."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/19.24.6675"xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/author | "Thacker J."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/author | "Deans B."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/author | "Maconochie M."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/author | "Griffin C.S."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/pages | "6675-6685"xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/title | "Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice."xsd:string |
| http://purl.uniprot.org/citations/11118202 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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