| http://purl.uniprot.org/citations/11120754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11120754 | http://www.w3.org/2000/01/rdf-schema#comment | "Pemphigus is an autoimmune disease of skin adhesion associated with autoantibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (Dsg) 1 and 3 and acetylcholine receptors. The notion that anti-Dsg antibodies alone are responsible for blisters in patients with pemphigus vulgaris (PV) stems from the ability of rDsg1 and rDsg3 to absorb antibodies that cause PV-like skin blisters in neonatal mice. Here, we demonstrate that PV IgGs eluted from rDsg1-Ig-His and rDsg3-Ig-His show similar antigenic profiles, including the 38-, 43-, 115-, and 190-kDa keratinocyte proteins and a non-Dsg 3 130-kDa polypeptide present in keratinocytes from Dsg 3 knockout mouse. We injected into Dsg 3-lacking mice the PV IgGs that did not cross-react with the 160-kDa Dsg 1 or its 45-kDa immunoreactive fragment and that showed no reactivity with recombinant Dsg 1. We used both the Dsg3(null) mice with a targeted mutation of the Dsg3 gene and the "balding" Dsg3(bal)/Dsg3(bal) mice that carry a spontaneous null mutation in Dsg3. These PV IgGs caused gross skin blisters with PV-like suprabasal acantholysis and stained perilesional epidermis in a fishnet-like pattern, indicating that the PV phenotype can be induced without anti-Dsg 3 antibody. The anti-Dsg 1 antibody also was not required, as its presence in PV IgG does not alter the PV-like phenotype in skin organ cultures and because pemphigus foliaceus IgGs produce a distinct phenotype in Dsg3(null) mice. Therefore, mucocutaneous lesions in PV patients could be caused by non-Dsg antibodies."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci10305"xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/author | "Shultz L.D."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/author | "Grando S.A."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/author | "Ndoye A."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/author | "Nguyen V.T."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/author | "Pittelkow M.R."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/pages | "1467-1479"xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/title | "Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions."xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/11120754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11120754 |
| http://purl.uniprot.org/citations/11120754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11120754 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGP6-mappedCitation-11120754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/#_O35902-mappedCitation-11120754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/#_Q61495-mappedCitation-11120754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/#_Q3UFC6-mappedCitation-11120754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/Q3UFC6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/Q61495 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/O35902 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11120754 |
| http://purl.uniprot.org/uniprot/A0A3Q4EGP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11120754 |