| http://purl.uniprot.org/citations/11121871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11121871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11121871 | http://www.w3.org/2000/01/rdf-schema#comment | "The antinociceptive effect and potential antinociceptive mechanism of Buthus martensi Karsch agonist of skeletal-muscle RyR-1 (BmK AS-1), a scorpion venom derived neurotoxic polypeptide, have been investigated in rats. The results show that: (a) the withdrawal latency to rat plantar radiant heat was increased significantly by 100 and 150% after intrathecal injection of 0.6 and 1.2 microg doses; (b) C components of rat nociceptive flexion reflex were reduced to 72, 50 and 29% after intraplantar injection of 5, 10 and 20 microg doses; (c) both central (spinal cord) and peripheral antinociceptive effects of BmK AS-1 could not be reversed by naloxone; (d) tetrodotoxin-resistant (TTX-R) Na(+) current was depressed to 83.87+/-1.64, 64.73+/-5.43 and 15.85+/-17.63%, and tetrodotoxin-sensitive (TTX-S) Na(+) current was depressed to about 81.27+/-2.5, 49.08+/-8.09 and 9.03+/-12.34% with 0.2, 1.0 and 10 microg/ml BmK AS-1 measured using patch clamp recording in rat small dorsal root ganglion (DRG) neurons, respectively. The results indicate that BmK AS-1 may be a new component with potent antinociceptive activity mediated by modulating TTX-S and TTX-R Na(+) channels."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0304-3940(00)01642-6"xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0304-3940(00)01642-6"xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Mao X."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Mao X."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Xiao H."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Zhao Z.-Q."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Zhao Z.-Q."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Ji Y.-H."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Ji Y.-H."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Tan Z.-Y."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/author | "Tan Z.-Y."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/name | "Neurosci. Lett."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/name | "Neurosci. Lett."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/pages | "65-68"xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/pages | "65-68"xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/title | "Buthus martensi Karsch agonist of skeletal-muscle RyR-1, a scorpion active polypeptide: antinociceptive effect on rat peripheral nervous system and spinal cord, and inhibition of voltage-gated Na(+) currents in dorsal root ganglion neurons."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/title | "Buthus martensi Karsch agonist of skeletal-muscle RyR-1, a scorpion active polypeptide: antinociceptive effect on rat peripheral nervous system and spinal cord, and inhibition of voltage-gated Na(+) currents in dorsal root ganglion neurons."xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/11121871 | http://purl.uniprot.org/core/volume | "297"xsd:string |