http://purl.uniprot.org/citations/11125885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11125885 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo examine whether polymorphism in the RANTES gene is associated with HIV disease outcome.DesignRANTES, a ligand of the major HIV co-receptor, CCR5, is known to block HIV-CCR5 interactions. Recently, two single nucleotide polymorphisms in the RANTES gene promoter region, designated -403G/A and -28C/G, have been described. Both polymorphisms can affect in-vitro promoter activity, and the RANTES -403A, -28G haplotype has been associated with a slower CD4 cell count decline rate in a Japanese cohort.MethodsWe compared RANTES compound genotype frequencies between HIV-positive and exposed-uninfected participants of the Multicenter AIDS Cohort Study (MACS) and rates of progression to AIDS for MACS seroconverters.ResultsWe found that the two most common RANTES promoter compound genotypes, G1 (-403G/G, -28C/C) found in 67% of Caucasians, and G4 (-403G/A, -28C/C) found in 23% of Caucasians, were associated with altered risk of HIV transmission and progression, particularly in individuals who lacked the protective CCR5 mutation, CCR5delta32. In this study, individuals with a G4 compound genotype were more likely to acquire HIV than individuals with a G1 compound genotype (OR 1.72, P = 0.016) and the risk increased when individuals possessing CCR5delta32 were omitted from consideration (OR 2.13, P = 0.005). Among seroconverters lacking CCR5delta32, those who had the G4 compound genotype progressed significantly slower to AIDS-1993 than those with the G1 compound genotype (median time to AIDS 7.6 versus 5.4 years; RH 0.65; P = 0.007).ConclusionsThese data implicate the RANTES-403A allele as a risk factor for HIV transmission and as a protective factor for HIV progression."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.org/dc/terms/identifier | "doi:10.1097/00002030-200012010-00006"xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Murphy P.M."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Boatin B.A."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Zimmerman P.A."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "McDermott D.H."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Hajeer A.H."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Ollier W.E."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Detels R."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Al-Sharif F.M."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Beecroft M.J."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Kleeberger C.A."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/author | "Leitman S.F."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/date | "2000"xsd:gYear |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/name | "AIDS"xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/pages | "2671-2678"xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/title | "Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study."xsd:string |
http://purl.uniprot.org/citations/11125885 | http://purl.uniprot.org/core/volume | "14"xsd:string |
http://purl.uniprot.org/citations/11125885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11125885 |
http://purl.uniprot.org/citations/11125885 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11125885 |
http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-11125885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11125885 |
http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-11125885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11125885 |
http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-11125885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11125885 |
http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-11125885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11125885 |