| http://purl.uniprot.org/citations/11136466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11136466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11136466 | http://www.w3.org/2000/01/rdf-schema#comment | "Low environmental pH strongly affected the organization of the Saccharomyces cerevisiae cell wall, resulting in rapidly induced resistance to beta1,3-glucanase. At a molecular level, we found that a considerable amount of Cwp1p became anchored through a novel type of linkage for glycosylphosphatidylinositol (GPI)-dependent cell wall proteins, namely an alkali-labile linkage to beta1,3-glucan. This novel type of modification for Cwp1p did not require the presence of a GPI-derived structure connecting the protein with beta1,6-glucan. In addition, we found high levels of Cwp1p, which was double-anchored through both the novel alkali-sensitive bond to beta1,3-glucan and the alkali-resistant GPI-derived linkage to beta1,6-glucan. Further cell wall analyses demonstrated that Pir2p/Hsp150 and possibly other Pir cell wall proteins, which were already known to be linked to the beta1,3-glucan framework by an alkali-sensitive linkage, were also more efficiently retained in the cell wall at pH 3.5 than at pH 5.5. Consequently, the alkali-sensitive type of linkage of cell wall proteins to beta1,3-glucan was induced by low pH. The low pH-induced alterations in yeast cell wall architecture were demonstrated to be dependent on a functional HOG1 gene, but not on the Slt2p-mediated MAP kinase pathway. Consistent with this observation, DNA microarray studies revealed transcriptional induction of many known high-osmolarity glycerol (HOG) pathway-dependent genes, including four cell wall-related genes, namely CWP1, HOR7, SPI1 and YGP1."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.2001.02242.x"xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.2001.02242.x"xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "ter Riet B."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "ter Riet B."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Klis F.M."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Klis F.M."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Vink E."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Vink E."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Kapteyn J.C."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Kapteyn J.C."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Blad S."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Blad S."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "De Nobel H."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "De Nobel H."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Van Den Ende H."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/author | "Van Den Ende H."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/pages | "469-479"xsd:string |
| http://purl.uniprot.org/citations/11136466 | http://purl.uniprot.org/core/pages | "469-479"xsd:string |