| http://purl.uniprot.org/citations/11138001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11138001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11138001 | http://www.w3.org/2000/01/rdf-schema#comment | "Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males 16-25 days after birth, and is characterized by overproliferation of CD4+CD8-T lymphocytes, extensive multiorgan infiltration and elevation of numerous cytokines. Similar to animals that lack expression of either Ctla-4 or Tgf-beta, the pathology observed in sf mice seems to result from an inability to properly regulate CD4+CD8-T-cell activity. Here we identify the gene defective in sf mice by combining high-resolution genetic and physical mapping with large-scale sequence analysis. The protein encoded by this gene (designated Foxp3) is a new member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved in humans. In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.org/dc/terms/identifier | "doi:10.1038/83784"xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.org/dc/terms/identifier | "doi:10.1038/83784"xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Wilkinson J.E."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Wilkinson J.E."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Hjerrild K.A."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Hjerrild K.A."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Clark L.B."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Clark L.B."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Ziegler S.F."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Ramsdell F."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Ramsdell F."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Brunkow M.E."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Brunkow M.E."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Galas D."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Galas D."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Jeffery E.W."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Jeffery E.W."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Paeper B."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Paeper B."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Yasayko S.-A."xsd:string |
| http://purl.uniprot.org/citations/11138001 | http://purl.uniprot.org/core/author | "Yasayko S.-A."xsd:string |