| http://purl.uniprot.org/citations/11146006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11146006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11146006 | http://www.w3.org/2000/01/rdf-schema#comment | "Threonine(668) (thr(668)) within the carboxy-terminus of the Alzheimer's disease amyloid precursor protein (APP) is a known in vivo phosphorylation site. Phosphorylation of APPthr(668) is believed to regulate APP function and metabolism. Thr(668) precedes a proline, which suggests that it is targeted for phosphorylation by proline-directed kinase(s). We have investigated the ability of four major neuronally active proline-directed kinases, cyclin dependent protein kinase-5, glycogen synthase kinase-3 beta, p42 mitogen-activated protein kinase and stress-activated protein kinase-1b, to phosphorylate APPthr(668) and report here that SAPK1b induces robust phosphorylation of this site both in vitro and in vivo. This finding provides a molecular framework to link cellular stresses with APP metabolism in both normal and disease states."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2001.00102.x"xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.2001.00102.x"xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Brownlees J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Brownlees J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Grierson A.J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Grierson A.J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Kesavapany S."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Kesavapany S."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Lau K.-F."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Lau K.-F."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "McLoughlin D.M."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "McLoughlin D.M."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Miller C.C.J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Miller C.C.J."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Standen C.L."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/author | "Standen C.L."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/pages | "316-320"xsd:string |
| http://purl.uniprot.org/citations/11146006 | http://purl.uniprot.org/core/pages | "316-320"xsd:string |