| http://purl.uniprot.org/citations/11148215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11148215 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11148215 | http://www.w3.org/2000/01/rdf-schema#comment | "The minus-ended microtubule motor cytoplasmic dynein contains a number of low molecular weight light chains including the 14-kDa Tctex-1. The assembly of Tctex-1 in the dynein complex and its function are largely unknown. Using partially deuterated, (15)N,(13)C-labeled protein samples and transverse relaxation-optimized NMR spectroscopic techniques, the secondary structure and overall topology of Tctex-1 were determined based on the backbone nuclear Overhauser effect pattern and the chemical shift values of the protein. The data showed that Tctex-1 adopts a structure remarkably similar to that of the 8-kDa light chain of the motor complex (DLC8), although the two light chains share no amino acid sequence homology. We further demonstrated that Tctex-1 binds directly to the intermediate chain (DIC) of dynein. The Tctex-1 binding site on DIC was mapped to a 19-residue fragment immediately following the second alternative splicing site of DIC. Titration of Tctex-1 with a peptide derived from DIC, which contains a consensus sequence R/KR/KXXR/K found in various Tctex-1 target proteins, indicated that Tctex-1 binds to its targets in a manner similar to that of DLC8. The experimental results presented in this study suggest that Tctex-1 is likely to be a specific cargo adaptor for the dynein motor complex."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011358200"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m011358200"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Lo K.W."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Lo K.W."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Mok Y.K."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/author | "Mok Y.K."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/pages | "14067-14074"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/pages | "14067-14074"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/title | "Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/title | "Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain."xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://purl.uniprot.org/core/volume | "276"xsd:string |
| http://purl.uniprot.org/citations/11148215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11148215 |
| http://purl.uniprot.org/citations/11148215 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11148215 |
| http://purl.uniprot.org/citations/11148215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11148215 |
| http://purl.uniprot.org/citations/11148215 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11148215 |