| http://purl.uniprot.org/citations/11149944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11149944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11149944 | http://www.w3.org/2000/01/rdf-schema#comment | "Cutaneous T-cell lymphomas (CTCL) are a group of skin neoplasms that originate from T lymphocytes and are difficult to treat in advanced stages. The present study is aimed at the identification of tumor-specific antigens from a human testis cDNA library using human sera known as the SEREX (serological identification of recombinantly expressed genes) approach. A cDNA library from normal testicle tissue was prepared and approximately 2 million recombinants were screened with sera from Sézary Syndrome and Mycosis fungoides patients. A total of 28 positive clones belonging to 15 different genes/ORFs were identified, including five hitherto unknown sequences. Whereas control sera did not react with most clones, 11-71% sera from CTCL patients were reactive against the identified clones. Expression analysis on 28 normal control and 17 CTCL tissues by reverse transcription-PCR (RT-PCR) and Northern blotting revealed seven ubiquitously distributed antigens, six differentially expressed antigens (several normal tissues were positive), and two tumor-specific antigens that were expressed only in testis and tumor tissues: (i) A SCP-1-like sequence, which has already been detected in various tumors, has been found in one CTCL tumor and four sera of CTCL patients reacted with various SCP-1-like clones and (ii) a new sequence named cTAGE-1 (CTCL-associated antigen 1) was detected in 35% of CTCL tumor tissues and sera of 6/18 patients reacted with this clone. The present study unravels CTCL-associated antigens independent of the T-cell receptor. The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.98.2.629"xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.98.2.629"xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.021386498"xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Dummer R."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Dummer R."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Eichmueller S."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Eichmueller S."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Schadendorf D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Schadendorf D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Thiel D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Thiel D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Stein A."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Stein A."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Usener D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/author | "Usener D."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/pages | "629-634"xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/pages | "629-634"xsd:string |
| http://purl.uniprot.org/citations/11149944 | http://purl.uniprot.org/core/title | "Serological detection of cutaneous T-cell lymphoma-associated antigens."xsd:string |