| http://purl.uniprot.org/citations/11154276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11154276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11154276 | http://www.w3.org/2000/01/rdf-schema#comment | "The Akt family of serine/threonine-directed kinases promotes cellular survival in part by phosphorylating and inhibiting death-inducing proteins. Here we describe a novel functional interaction between Akt and apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase. Akt decreased ASK1 kinase activity stimulated by both oxidative stress and overexpression in 293 cells by phosphorylating a consensus Akt site at serine 83 of ASK1. Activation of the phosphoinositide 3-kinase (PI3-K)/Akt pathway also inhibited the serum deprivation-induced activity of endogenous ASK1 in L929 cells. An association between Akt and ASK1 was detected in cells by coimmunoprecipitation. Phosphorylation by Akt inhibited ASK1-mediated c-Jun N-terminal kinase and activating transcription factor 2 activities in intact cells. Finally, activation of the PI3-K/Akt pathway reduced apoptosis induced by ASK1 in a manner dependent on phosphorylation of serine 83 of ASK1. These results provide the first direct link between Akt and the family of stress-activated kinases."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.3.893-901.2001"xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.21.3.893-901.2001"xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Chao M.V."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Chao M.V."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Franke T.F."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Franke T.F."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Khursigara G."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Khursigara G."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Kim A.H."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/author | "Kim A.H."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/pages | "893-901"xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/pages | "893-901"xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/title | "Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/title | "Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1."xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11154276 | http://purl.uniprot.org/core/volume | "21"xsd:string |