| http://purl.uniprot.org/citations/11157754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11157754 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor-beta (TGF-beta) signals through membrane-bound serine/threonine kinase receptors, which upon stimulation phosphorylate Smad proteins and thereby trigger their nuclear translocation and transcriptional activity. Although the three mammalian isoforms of TGF-beta are highly homologous at the level of sequence, analysis of their in vivo function by gene knockouts revealed striking differences, suggesting no significant functional redundancy between TGF-beta1, -2 and -3. While signal transduction by TGF-beta1 has been well characterized, receptor binding and activation by the TGF-beta2 isoform is less well understood. Here, we show that TbetaRII-B, an alternatively spliced variant of the TGF-beta type II receptor, is a TGF-beta2 binding receptor, which mediates signalling via the Smad pathway in the absence of any TGF-beta type III receptor (TbetaRIII). L6 cells lacking endogenous TbetaRIII as well as TbetaRII-B do not respond to TGF-beta2. Transfection of these cells with TbetaRII-B restores TGF-beta2 sensitivity. The expression of TbetaRII-B is restricted to cells originating from tissues such as bone where the isoform TGF-beta2 has a predominant role. This reflects the importance of this receptor in TGF-beta isoform-specific signalling."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/20.3.480"xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Roth M."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Lutz M."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Lindemann D."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Sebald W."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Knaus P."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/author | "Rotzer D."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/pages | "480-490"xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/title | "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/11157754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11157754 |
| http://purl.uniprot.org/citations/11157754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11157754 |
| http://purl.uniprot.org/uniprot/P10600#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/P10600#attribution-E0F62E80B5EAC4DA5E0FD1535670BD5B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/P01137#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/P36897#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/P37173#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/P61812#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/Q03167#attribution-934D56D62412A10F83B0C0578075AA46 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |
| http://purl.uniprot.org/uniprot/Q03167#attribution-E271166A46F78A1371ABD39ABA2FD19F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11157754 |