| http://purl.uniprot.org/citations/11157975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11157975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11157975 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified a novel adaptor protein that contains a Src homology (SH)3 domain, SH3 binding proline-rich sequences, and a leucine zipper-like motif and termed this protein WASP interacting SH3 protein (WISH). WISH is expressed predominantly in neural tissues and testis. It bound Ash/Grb2 through its proline-rich regions and neural Wiskott-Aldrich syndrome protein (N-WASP) through its SH3 domain. WISH strongly enhanced N-WASP-induced Arp2/3 complex activation independent of Cdc42 in vitro, resulting in rapid actin polymerization. Furthermore, coexpression of WISH and N-WASP induced marked formation of microspikes in Cos7 cells, even in the absence of stimuli. An N-WASP mutant (H208D) that cannot bind Cdc42 still induced microspike formation when coexpressed with WISH. We also examined the contribution of WISH to a rapid actin polymerization induced by brain extract in vitro. Arp2/3 complex was essential for brain extract-induced rapid actin polymerization. Addition of WISH to extracts increased actin polymerization as Cdc42 did. However, WISH unexpectedly could activate actin polymerization even in N-WASP-depleted extracts. These findings suggest that WISH activates Arp2/3 complex through N-WASP-dependent and -independent pathways without Cdc42, resulting in the rapid actin polymerization required for microspike formation."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.152.3.471"xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.152.3.471"xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Endo T."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Suetsugu S."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Suetsugu S."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Fukami K."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Fukuoka M."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/author | "Fukuoka M."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/pages | "471-482"xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/pages | "471-482"xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/title | "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42."xsd:string |
| http://purl.uniprot.org/citations/11157975 | http://purl.uniprot.org/core/title | "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42."xsd:string |