| http://purl.uniprot.org/citations/11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11158011 | http://www.w3.org/2000/01/rdf-schema#comment | "We assessed the prevalence of families with both type 1 and type 2 diabetes in Finland; and we studied, in patients with type 2 diabetes, the association between a family history of type 1 diabetes, glutamic acid decarboxylase (GAD) antibodies (GADab), and type 1 diabetes-associated human leukocyte antigen (HLA) DQB1-genotypes. Further, in mixed type 1/type 2 diabetes families, we investigated whether sharing an HLA haplotype with a family member with type 1 diabetes influenced the manifestation of type 2 diabetes. Among 695 families ascertained through the presence of more than 1 patient with type 2 diabetes, 100 (14%) also had members with type 1 diabetes. Type 2 diabetic patients from the mixed families had, more often, GADab (18% vs. 8%, P < 0.0001) and DQB1*0302/X genotype (25% vs. 12%, P = 0.005) than patients from families with only type 2 diabetes; but they had a lower frequency of DQB1*02/0302 genotype, compared with adult-onset type 1 patients (4% vs. 27%, P < 0.0001). In the mixed families, the insulin response to oral glucose load was impaired in patients who had HLA class II risk haplotypes, either DR3(17)-DQA1*0501-DQB1*02 or DR4*0401/4-DQA1*0301-DQB1*0302, compared with patients without such haplotypes (P = 0.016). This finding was independent of the presence of GADab. We conclude that type 1 and type 2 diabetes cluster in the same families. A shared genetic background with a patient with type 1 diabetes predisposes type 2 diabetic patients both to autoantibody positivity and, irrespective of antibody positivity, to impaired insulin secretion. The findings support a possible genetic interaction between type 1 and type 2 diabetes mediated by the HLA locus."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.org/dc/terms/identifier | "doi:10.1210/jcem.86.2.7170"xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Almgren P."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Tuomi T."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Lindholm E."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Gustafsson A."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/author | "Forsblom C."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/name | "J Clin Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/pages | "574-582"xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/title | "Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes."xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/11158011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11158011 |
| http://purl.uniprot.org/citations/11158011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I5-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAC7-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE6-mappedCitation-11158011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11158011 |