| http://purl.uniprot.org/citations/11160248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11160248 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-15, a pleiotropic cytokine, is involved in the inflammatory responses in various infectious and autoimmune diseases. We have recently constructed IL-15-transgenic (Tg) mice, which have an increased number of memory-type CD8+ T cells in the peripheral lymphoid tissues. In the present study, we found that eosinophilia and Th2-type cytokine production in the airway were severely attenuated in OVA-sensitized IL-15-Tg mice following OVA inhalation. IL-15-Tg mice preferentially developed Tc1 responses mediated by CD8+ T cells after OVA sensitization, and in vivo depletion of CD8+ T cells by anti-CD8 mAb aggravated the allergic airway inflammation in IL-15-Tg mice following OVA inhalation. Adoptive transfer of CD8+ T cells from OVA-sensitized IL-15-Tg mice into normal mice before OVA sensitization suppressed Th2 response to OVA in the normal mice. These results suggest that overexpression of IL-15 in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.3.1991"xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Nishimura H."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Yajima T."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Kawauchi H."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Watase T."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/author | "Ishimitsu R."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/pages | "1991-2001"xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/title | "Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in a murine model of asthma."xsd:string |
| http://purl.uniprot.org/citations/11160248 | http://purl.uniprot.org/core/volume | "166"xsd:string |
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