| http://purl.uniprot.org/citations/11160324 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11160324 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging has been associated with intrinsic changes of the humoral immune response, which may lead to an increased occurrence of autoimmune disorders and pathogenic susceptibility. The transcription factor Pax-5 is a key regulator of B cell development. Pax-5a/B cell-specific activator protein and an alternatively spliced isoform, Pax-5d, may have opposing functions in transcriptional regulation due to the lack of a transactivation domain in Pax-5d. To study B cell-specific changes that occur during the aging process, we investigated expression patterns of Pax-5a and 5d in mature B cells of young and aged mice. RNase protection assays showed a similar transcriptional pattern for both age groups that indicates that aging has no affect on transcription initiation or alternative splicing for either isoform. In contrast, a significant reduction in the DNA binding activity of Pax-5a but not Pax-5d protein was observed in aged B cells in vitro, while Western blot analyses showed that similar levels of Pax-5a and 5d proteins were present in both age groups. The observed decrease in Pax-5a binding activity correlated with changes in expression of two Pax-5 target genes in aged B cells. Expression of the Ig J chain and the secreted form of Ig mu, which are both known to be suppressed by Pax-5a in mature B cells, were increased in B cells of aged mice. Together, our studies suggest that changes associated with the aging phenotype cause posttranslational modification(s) of Pax-5a but not Pax-5d, which may lead to an abnormal B cell phenotype in aged mice, associated with elevated levels of J chain, and secretion of IgM."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.166.4.2617"xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/author | "Zwollo P."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/author | "Pollock R."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/author | "Kaattari I."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/author | "Anspach J."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/author | "Poulsen G."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/pages | "2617-2626"xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/title | "Reduction in DNA binding activity of the transcription factor Pax-5a in B lymphocytes of aged mice."xsd:string |
| http://purl.uniprot.org/citations/11160324 | http://purl.uniprot.org/core/volume | "166"xsd:string |
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